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This technology consists of 12 K. pneumoniae strains that which have been genetically engineered to carry mutations affecting key cell functions known to be implicated in the development of drug resistance including antimicrobial efflux, virulence, transcription factor regulation and membrane stability. These are useful set of strains for use in antibiotic drug discovery and screening.
The technology is a text-mining tool, which identifies the reporting of measures to reduce the risk of bias in biomedical research publications. This would allow stakeholders, such as publishing groups and funding agencies, to assess the quality of their output, increasing confidence in the results and minimising the waste of resources on unreliable research.
Notch-3 signalling is the key driver of tumour development in bile duct cancer, with Notch-3 receptor differentially overexpressed in comparison to other notch receptors. Therapeutic targeting of this receptor could provide anti-tumorigenic effects in patients, and act as a chemotherapeutic agent with minimal side-effects.